COT
COT Secretariat
COT Secretariat
Food Standards Agency
Aviation House
125 Kingsway
London WC2B 6NH
Tel: 020 7276 8522
Fax: 020 7276 8513
cot@foodstandards.gsi.gov.uk
- Sponsoring departments
- Food Standards Agency
- Department of Health
- Sister committees
- Committee on Carcinogenicity
- Committee on Mutagenicity
- More links >>
Search
COT agenda and papers: 6 December 2005
Agenda and papers for the meeting of the Committee at 10.00am on Tuesday 6 December 2005 in Rooms 4 and 5, 4th Floor, Aviation House, London.
Please note that the final discussion item on the agenda (2-Chlorobenzylidene Malonnitrile (CS) and PAVA (Nonovamide) sprays – combined use – TOX/2005/31) will be held in closed session.
1. Apologies for absence
2. Draft minutes of the meeting held on 18th October 2005 - TOX/MIN/2005/05
3. Matters arising
4. Risk assessment and monitoring of marine biotoxins in support of public health - TOX/2005/35
The Committee is asked for its view on the risk assessment of biotoxins in shellfish, and on the best method(s) of testing for shellfish biotoxins to support protection of health of the consumer.
5. Uranium levels in water used to re-constitute infant formula - TOX/2005/33
At the October COT meeting, Members considered a paper on the uranium levels in natural mineral waters with regard to use for reconstituting infant feed. Members required additional information about the critical study used to establish the World Health Organisation Tolerable Daily Intake (TDI) for uranium in drinking water and also asked for further details on the other studies considered by WHO and on any available epidemiology. These papers have been provided and are presented to the Committee for consideration.
6. Tryptophan in food: responses to consultation on revision of the Regulations - TOX/2005/34
In June 2004 the Committee published a statement on tryptophan and Eosinophilia Myalgia Syndrome. This concluded that a dose of 220 mg tryptophan per day as a dietary supplement would not present an appreciable risk to health, providing that it meets the purity criteria specified in the European Pharmacopoeia.
Following the publication of the statement, the FSA proposed a revision to the Tryptophan in Food (England) Regulations 1990, in which a maximum daily dose of 220 mg was proposed and purity criteria specified. The proposals were consulted on in early 2005. A number of responses were received included a detailed paper from the Institute of Optimum Nutrition (ION). In light of the responses to the consultation and updated information received, the Committee is asked whether the additional information presented here reduces the uncertainty in the assessment, such that a higher dose could be identified as not anticipated to have adverse effects.
7. Kava kava in food products - TOX/2005/32
In 2002 the Food Standards Agency asked the Committee for its urgent advice on the herbal preparation kava kava and the kava kava in Food (England) Regulations were laid before Parliament. In February 2005, the FSA consulted with stakeholders to assess whether any further information had emerged on kava kava. The COT is invited to consider whether the new information alters its previous conclusions.
8. Preliminary discussion on combination brominated organic contaminants for toxicological evaluation - TOX/2005/36
This paper requests the COT's preliminary advice on the brominated dioxin-like compounds PBDDs, PBDFs and PBBs. This request particularly relates to how data on large numbers of congeners should be combined, taking into account the COT's previous approaches to evaluation of mixtures of related compounds.
9. 2-Chlorobenzylidene Malonnitrile (CS) and PAVA (Nonovamide) sprays – combined use. (TOX/2005/31) This item will be held in closed session
The Committee has been asked by the Home Office Science Development Branch (HOSDB) for advice on the potential effects of exposure to both 2-chlorobenzylidene malonitrile (CS) and pelargonic acid vanillylamide (PAVA). To date, there is no known incident where co-exposure has occurred. At the request of the HOSDB the discussion will be held in closed session as there is a need to formulate policy in this area.
Paper for information
- Minutes of COM and COC meetings - TOX/2005/37
- Provisional programme for the open meeting on the development and function in adulthood of the male reproductive system - potential chemical induced effects - TOX/2005/38