GM safety assessment

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• Determination of inauthentic protein glycosylation in transgenic plants

  This project sought to develop robust methodologies to characterise the glycosylation of transgenic plant proteins for application in risk assessments.

• Development of models for the analysis of metabolome variability in crops

  This project addresses the need to have baseline metabolomic data for crops, to use as a reference in assessing new crop varieties (GM or non-GM). It also addresses how the quality of the raw data used for assessment purposes may affect the safety assessment.

• Factors influencing transgene survival and transfer in the rumen

  This project examined the fate of transgenic DNA in genetically modified (GM) food/feed in the gut of farm animals. In vivo experiments together with in vitro modelling techniques and real-time polymerase chain reaction (PCR) were used to examine DNA survival and the potential for gene transfer to the gut microflora.

• MudPIT as a tool for the separation and quantification of proteins for GM crop safety assessments

  This research project aimed to assess the potential of multidimensional protein identification technology (MudPIT) as quantitative procedure to ascertain protein perturbations arising from genetic modifications.

• Procedure development for the isolation of transgene flanking regions in GM crops and analysis of transgene insertion

  This project involved the refinement and validation of a rapid polymerase chain reaction (PCR) based method for characterisation of junction sequences in a range of genetically modified (GM) crops.