Research Programme M03: project details
Details of the Agency-funded projects under the Transmissable Spongiform Encephalopathies, including BSE, research programme (M03).
M03004: Transmissibility of BSE to pigs by oral exposure to brain homogenate
This research project aims to determine whether BSE can be transmitted to pigs by including infected material in their feed.
Results available.
M03005: Transmissibility of scrapie to pigs by oral exposure to brain homogenate
This research project aims to determine whether scrapie can be transmitted to pigs by including infected material in their feed.
M03006: Bioassay of BSE infectivity in non-neural tissues by intracerebral inoculation of cattle
This research project aims to determine the infectivity of different types of cattle tissue by whether BSE can be transmitted to cattle by injecting them with the tissues.
M03007: Bioassay of BSE infectivity in non-neural tissues by intracerebral inoculation of cattle
This research project aims to determine the infectivity of different types of cattle tissue by whether BSE can be transmitted to cattle by injecting them with the tissues.
M03009: Contamination by CNS material during standard butchering processes prevalent in the member states of the EU
This research project aims to determine if cattle carcasses are contaminated with spinal cord material from any one previously processed carcass.
Results available.
M03010: Further studies on the transmissibility of BSE to pigs
This research project aims to investigate further the results of the initial project (M03004) studying whether BSE can be transmitted to pigs.
M03012: Prevalence of CNS embolism and determination of potential for visceral dissemination at stunning and slaughter in cattle
This research project aims to determine the possibility of potentially infective material contaminating the blood of cattle after stunning with either penetrating or non-penetrating captive bolt guns.
M03013: Prevalence of CNS embolism and determination of potential for visceral dissemination at stunning and slaughter in sheep
This research project aims to determine whether neural tissue can contaminate sheep carcasses after stunning.
M03014: Epidemiological assessment of the potential risk to human health in GB posed by possible BSE infection within the national flock
This research project aims to assess the potential risk to human health if the sheep population was infected with BSE.
M03016: Determination of abnormal prion protein in the milk of cattle experimentally infected with BSE
This research project aims to determine whether the BSE infective agent is present in milk from cattle infected with BSE.
M03017: Removal of spinal column from cattle and sheep carcasses
This research project aims to develop an oval saw as an alternative to the splitting saw, in order to reduce or eliminate contamination of carcasses with spinal cord material.
M03018: Audit of the sources of BSE infectivity in human food
This research project aims to establish if bovine MRM was a significant source of BSE infected material and then to provide as much information on the historic use of MRM between 1980 and 1995.
Results available.
M03019: Identification of blood protein markers for TSE disease
This research project aims to investigate whether certain proteins present in blood could be used as a diagnostic test for BSE in cattle and CJD in humans.
M03020: Assessing EDRF as a potential marker for BSE
This research project aims to determine whether a protein found in blood called EDRF can be used to reliably diagnose preclinical cases of BSE in cattle and scrapie in sheep.
M03021: Epidemiological assessment of the risk to human health from BSE in GB cattle and of the potential impact of modifying existing control measures
This research project aims to estimate the current risk to human health of BSE in cattle and the effect on the risk of possible changes to the OTM rule.
Results available.
M03022: Review of current slaughtering methods for cattle and sheep that avoid risk of dissemination of brain particles into blood and carcass, and maintain good welfare and operator safety standards
This research project aims to evaluate existing and novel stunning methods used for stunning cattle and sheep with regard to animal welfare, public health and operator safety.
Results available.
M03023: Development of immunotests for Specified Risk Material (SRM)
This research project aims to develop a rapid, easy-to-use test for the detection of SRM in meat products.
M03024: Susceptibility of red deer (Cervus elaphus elaphus) to BSE
This research project aims to determine whether BSE can be transmitted to UK red deer by including infected material in their feed.
M03025: Development of physical techniques for non-invasive stunning of cattle, Phase 1 - Feasibility study
This research project aims to determine the feasibility of applying computer modelling techniques to achieve understanding and optimisation of cattle stunning.
M03026: Empirical determination of Central Nervous System (CNS) and Dorsal Root Ganglia (DRG) contamination of carcasses and its reduction using alternative procedures
This research project aims to determine the extent of contamination of carcasses with CNS tissue during dressing and develop methods to reduce this contamination.
M03027: How much sheep-TSE infectivity enters the human food chain? An assessment of risk reduction by removal of scrapie flocks
This research project aims to estimate the reduction in theoretical risk to the consumer if sheep from scrapie-infected flocks were removed from the food chain.
M03029: Audit of effective removal of Dorsal Root Ganglia (DRG) from carcasses
This research project aims to determine the extent of DRG contamination of meat and whether any new butchery practices need to be developed.
M03030: Diagnosis of TSE disease in cattle and sheep using metabolomic analysis and computer learning technologies
This research project aims to identify novel markers in the blood and urine of cattle and sheep that are consistently indicative of TSE infection and to develop a diagnostic test.
M03033: Risk assessment of options for change in Meat Hygiene Service (MHS) enforcement of Specified Risk Material (SRM) controls
This research project aims to evaluate the effect of possible changes in enforcement on the risk of exposure to BSE infectious material as part of a review of the MHS.
M03034: Detection of BSE prions from cattle and sheep using transgenic mice and conformation-dependent immunoassay
This research project aims to improve methods for the detection of BSE infection in cattle and sheep including differentiation between BSE and scrapie infection in sheep.
ZM0303: An investigation of the extent of tonsil tissue present in tongue meat
This research project aims to determine the extent of contamination of cattle tongue meat with tonsil tissue.
Results available.
ZM0304: Detection of metabolic markers for scrapie infected sheep using NMR spectroscopy
This research project aims to investigate whether a proposed technique could lead to a blood test for scrapie infection in sheep.
Results available.
ZM0306: Historic butchery practices
This research project aims to determine whether butchery practices prevalent in the Queniborough area, which may have resulted in the cluster of vCJD cases, were common practice in the UK.
ZM0307: Audit of sheep and goat products for potential BSE infectivity
This research project aims to characterise the consumption of sheep and goat products within the UK.
