M03010: Further studies on the transmissibility of BSE to pigs
Thursday 29 May 2003
This research project aims to investigate further the results of the initial project (M03004) studying whether BSE can be transmitted to pigs.
Background
Further investigation of the possible transmission of BSE to pigs is to be undertaken. The results of this study will enable a more informed approach to the diagnosis of TSE in the pig to be taken, and will answer in greater depth the question of possible infection of the national pig herd by feeding contaminated meat and bonemeal (MBM).
Research Approach
The study will involve investigation of the pathology by immunocytochemistry, investigation of the, presumably incidental, vacuolation of the rostral colliculi by examination of pigs from outside of the UK and of pigs alive prior to the appearance of BSE in 1986 by passage of the rostral colliculi of unchallenged control pigs into pigs parenterally challenged. In addition further examination will be carried out of the apparently normal brains from pigs orally challenged with BSE to confirm lack of transmission by this route.