Project details - Phytoestrogen research programme (T05/T06)
Details of the Agency-funded projects under the Phytoestrogen research programmes T05 and T06.
T05001: Synthesis of labelled and unlabelled isoflavonoid phytoestrogen standards
This research project aims to produce analytical standards for the accurate measurement of phytoestrogens in food.
T05002: Possible beneficial effects of dietary phytoestrogens in men
This research project aims to investigate the effect of phytoestrogens on prostate cancer, DNA damage in blood cells, cholesterol levels in the blood and sperm production.
Results available.
T05003: Possible beneficial and adverse effects of dietary phytoestrogens on prostate cancer
This research project aims to investigate the effect of dietary phytoestrogens on the development of prostate cancer.
Results available.
T05004: Effects of phytoestrogens and related dietary components on bone metabolism
This research project aims to determine whether bone loss in post-menopausal women can be reduced by supplementing the diet with phytoestrogens.
Results available.
T05005: Development and application of screening assays for the beneficial and adverse effects of phytoestrogens in food
This research project aims to develop more versatile and sensitive methods to detect phytoestrogens in food.
Results available.
T05006: Investigation of the post-natal developmental toxicity of an isoflavone
This research project aims to examine the effects that one phytoestrogen (an isoflavone) has on post-natal development.
Results available.
T05009: The use of 13C isomers as analytical standards and as tracers of phytoestrogens in humans
This research project aims to produce analytical standards for the accurate measurement of phytoestrogens in food.
Results available.
T05010: Absorption and metabolism of dietary phytoestrogens in humans - effect of age, gender, food matrix and chemical composition
This research project aims to measure the absorption and metabolism of one group of phytoestrogens (the isoflavones) in humans.
Results available.
T05011: Influence of human gut microflora on dietary soya isoflavone phytoestrogen bioavailability in adults and children
This research project aims to determine what effects the microflora (bacteria) in the gut have on the metabolism and levels of phytoestrogens in the blood and urine of adults and children.
Results available.
T05013: Do dietary phytoestrogens protect against cancer in genetically susceptible groups by disrupting the metabolism of endogenous oestrogens?
This research project aims to determine whether phytoestrogens can influence the development of breast cancer.
Results available.
T05014: The effect of phytoestrogen ingestion on menopausal women
This research project aims to determine whether supplementation of the diet with one group of phytoestrogens found in linseed (lignans) can relieve menopausal symptoms.
Results available.
T05015: Diet, phytoestrogen and gene/nutrient interactions in relation to cancer - a prospective study
This research project aims to investigate the possible effects of phytoestrogen consumption on the development of breast and prostate cancer.
Results available.
T05016: Genomics, microarrays and a transgenic reporter model in the study of phytoestrogen effects on oestrogen receptor mediated gene transcription
This research project aims to examine the mechanism of action of dietary phytoestrogens by looking at gene expression after exposure to these compounds.
Results available.
T05018: Consensus review of the Food Standards Agency's Phytoestrogens Programme
This research project aims to review the Phytoestrogens Research Programme and conduct a survey of phytoestrogen research worldwide.
Results available.
T05019: Absorption, distribution and metabolism of isoflavones in vivo
This research project aims to determine the fate of phytoestrogens in the human body.
Results available.
T05020: Absorption, distribution, metabolism and excretion of 14C labelled genistein
This research project aims to determine the fate of phytoestrogens (specifically genistein, an isoflavone) within the body and whether this differs in males and females.
Results available.
T05021: Quality assurance scheme for phytoestrogens
This research project aims to provide a quality assurance analysis of the main methods currently used to measure phytoestrogens in food.
Results available.
T05022: Biological effects of phytoestrogens
This research project aims to measure the phytoestrogen content of food commonly consumed in the UK and to estimate the dietary intake of phytoestrogens by the UK population.
Results available.
T05023: Synthesis of phytoestrogen standards in labelled and unlabelled form
This research project aims to produce analytical standards for the accurate measurement of phytoestrogens in food.
Results available.
T05024: Quality Assurance Scheme for the Food Standards Agency's Phytoestrogens Research Programme
This research project aims to examine whether the analytical data obtained by contractors for the Phytoestrogens Research Programme is precise and consistent.
Results available.
T05025: Effects of ER beta overexpression on the molecular action of phytoestrogens
This research project aims to investigate the interactions of phytoestrogens with oestrogen receptors in breast, uterine and bone cells.
Results available.
T05027: Analysis of formaldehyde in Shiitake mushrooms
This research project aims to investigate the levels and origins of formaldehyde in Shiitake mushrooms, as well as the effects of cooking and storage on formaldehyde levels.
Results available.
T05028: Dietary and biomarker prospective study of phytoestrogens in breast and prostate cancer
This research project will develop a method for the analysis of phytoestrogens in foods enabling investigations into relationships of dietary intake of phytoestrogens and the risk of developing certain cancers.
T05029: A double blind placebo controlled crossover trial of soy phytoestrogens in patients with compensated hypothyroidism
This research project will determine if two different soya preparations have an effect on subjects with compensated hypothyroidism.
T05030: Investigation of the phytoestrogen intake of a group of post-menopausal women previously diagnosed with breast cancer
This research project aims to investigate phytoestrogen intake and systemic exposure to phytoestrogens in a group of post-menopausal women previously diagnosed with breast cancer.
T06001: Identification and quantification of dietary lignans by liquid chromatography and mass spectrometry
This research project aims develop an improved analytical method to quantify phytoestrogens in foods, and to determine how human exposure to dietary phytoestrogens is affected by gut microflora (bacteria).
Results available.
T06002: Phytoestrogen dietary supplement survey
This research project aims to determine the concentration of phytoestrogens in a range of dietary supplements to allow the possible health effects of their consumption to be assessed.
Results available.
T06003/T06004: Measurement of phytoestrogens in the UK diet
This research project aims to measure the amounts of phytoestrogens consumed in typical vegetarian and non-vegetarian UK diets.
Results available.