Diet and colonic health research programme - list of projects
Details of Agency-funded projects under the Diet and Colonic Health research programme (N12).
N02018: Vitamins C, E, DNA malonaldyde adducts in rectal biopsies and lymphocytes
This research project aims to find out whether a group of markers of DNA damage relevant to cancer would be useful in investigating the relationship between diet and the risk of cancer.
Results available.
N05028: Folic acid and colon health
This research project aims to investigate the relationship between folate status and colorectal cancer.
N05029: PCR and folic acid status
This research project aims to provide a rapid diagnostic test for effective monitoring of folate bioavailability.
Results available.
N12001 and N12005: Detection of CpG island methylation in faecal DNA
These research projects aim to identify biological changes marking the earliest stages of colorectal cancer and design ways to measure these changes and study their modification by diet.
Results available.
N12002 and N12007: The impact of folate and its interactions with riboflavin on biomarkers of colorectal cancer risk
These research projects aim to contribute a sound scientific basis for folate and riboflavin recommendations to the public to reduce colorectal cancer risk.
N12003: Novel DNA biomarkers for folate deficiency in surrogate tissues and colonic mucosa
This research project aims to identify biomarkers of folate deficiency and assess the effect of dietary folate supplementation on these.
N12004 and N12006: Applying proteomic technology to identify biomarkers of colorectal cancer
These research projects aim to identify biomarkers of colorectal cancer.
Results available.
N12008: Alkylated s-cysteine MGMT adducts as biomarkers of mutagenic agents in the colon
This research project aims to identify mutagenic agents that can cause colorectal cancer and lead to a better understanding of dietary factors that determine susceptibility.
N12009 and N12011: Developing biomarkers of colorectal neoplasia - quantification of aberrant CpG island methylation in human faecal DNA
These research projects aim to identify biological changes marking the earliest stages of colorectal cancer and design ways to measure these changes and study their modification by diet.
Results available.
N12012: Gastro-intestinal health with special emphasis on reduction of risk of colon cancer and inflammatory bowel disease (Fishgastro)
This research project aims to confirm whether fish consumption confers protection against disease of the colon and whether this protective effect is limited to oily fish.
N12014 : Faecal methylation, gene expression and disease outcome in people consuming fish (FishMet)
This research project aims to assess the impact of fish consumption on bowel health and to develop novel biomarkers of risk, which are amenable to dietary intervention.
N12015: Validation of novel diet-related biomarkers of early colorectal neoplasia-use of proteomic technology and identification of mitochondial DNA mutations.
This research project aims to identify diet related preclinical biomarkers of bowel cancer using state of the art technology including proteomics.
N12016: Markers of systemic and mucosal inflammation as biomarkers of vulnerability to colorectal cancer.
This research project will test the hypothesis that systemic inflammation (associated with high body-weight and adiposity) is causally linked with low-grade bowel mucosal inflammation, and that this condition is associated with higher risk of bowel cancer.
N12017: Protein acetylation as a diet-modifiable biomarker of colorectal cancer risk
This research project aims to identify novel biomarkers of preclinical carcinogenesis and investigate the extent to which these biomarkers are responsive to dietary intervention.