The species barrier has appeared to be efficient for limiting propagation of the TSE agent between animal species. One consequence of such a barrier is the apparent absence of natural transmission from a number of animal TSE agents to humans, however, that statement remains essentially based on epidemiological observations. Very little data is available in this field, however, in the case of cattle BSE its ability to cross the species barrier has been demonstrated. The recent discovery of atypical forms of BSE in cattle as well as atypical forms of scrapie in sheep raise the question of their transmissibility to humans.
The research will use Enzyme-Linked ImmunoSorbent Assays and western blot techniques to characterisation phenotypic features that are linked to a strain of TSE agent.
- Padilla, D., Béringue, V., Espinosa, J.C., Andréoletti, O., Jaumain, E., Reine, F., Herzog, L., Gutierrez-Adan, A., Pintado B., Laude H. & Torres J.M. (2011) Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice. Published online PLoS Pathogens 7: e1001319
- Espinosa, J.C., Herva, M.E., Andréoletti, O., Padilla, D., Lacroux,C., Cassard, H., Lantier, I., Castilla, J. & Torres, J.M. (2009) Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie. Emerging Infectious Diseases, 15, 1214-21