Project details - Risk assessment of food chemicals research programme T01

Last updated:
8 March 2004
Information about Agency-funded research projects
This research project addressed the issue of whether high maternal caffeine intake during pregnancy leads to an increased incidence of low birth weight babies.
Results available
Investigations of body burden of brominated compounds based on analysis of blood, liver and adipose tissue samples from obese and non-obese participants. The study will refine the risk assessment process for the obese population and its relationship with chemical levels in blood.
The report described the results of a controlled double blind study of consumption of an aspartame containing cereal bar in self-reported aspartame sensitive individuals and controls. No differences were observed in clinical, biochemical, psychological and metabonomic parameters following consumption of aspartame in either group.
Results available
This research project aims to develop methods to assess the health effects from mixtures of food chemicals by using four well characterised food additives.
Results available
This research project describes the development and use of probabilistic models to look at patterns of food consumption and intakes of food chemicals.
Results available
This short research project aims to add to existing information on the reported anticancer effects of eating cruciferous vegetables using samples collected as part for a previous FSA project.
Results available
This project investigated, using the in vitro binucleate micronucleus assay, whether the concept of non-linear, threshold dose-response relationships can be applied to at least a proportion of the potentially mutagenic chemicals found in food.
The study aimed to develop a scientific rationale for defining levels of concern associated with given values of margin of exposure (MOE) for genotoxic carcinogens. The relationship between the MOE and human cancer risk is uncertain and requires clearer understanding of mode/mechanism of action and implications for the dose-response relationship.
Results available
This research project aims to develop a suite of quantitative methods for assessing and integrating beneficial and adverse effects of foods as web-based software.
Dioxins are cumulative environmental pollutants (present in fat-containing foods) which activate aryl hydrocarbon receptors (AhRs). Dioxin-like compounds evaluated were shown to have very different potencies at AhRs in different species. It is not always possible to predict the potency in humans from in vitro (or rat in vivo) toxicity data.
Results available
This research project investigates whether PhIP, or its metabolites, influence cell proliferation and cell growth.
Results available
This research project investigated the effects of mixtures of food contaminants and additives with different modes of action.
Results available
This research project examines the effects of heterocyclic amines and oxidative agents on the level of DNA adduct formation and repair in liver cells
Results available